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Ten children received standard heparin, and 12 children received low-molecular-weight heparin (LMWH) (enoxaparin sodium). Eighteen children were treated with oral anticoagulants for 3 months after initial heparin therapy, and 4 patients received LMWH for the entire course of treatment. There was no intracranial hemorrhage in the 12 patients treated with LMWH, but there was 1 case of clinically silent bleeding in the standard heparin group. The results of this pilot study suggest that anticoagulant therapy, in particular LMWH, is safe and may have a role in treatment of children with SVT. A randomized controlled trial is warranted. |
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